Adding aripiprazole to olanzapine.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Agents with anticholinergic properties may have additive effects when used in combination. 
- ↑ 1.01.11.21.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Interactions between aripiprazole and olanzapine on drugs.com
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