Combining-Lithium-Quetiapine

Lithium
Type moodstabilizer
Group other
links
ATC-code N05AN01
Medscape Lithium
PubChem 11125
PubMed Lithium
Drugs.com lithium
Kompas (Dutch) Lithium
Wikipedia Lithium
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding quetiapine to lithium.

Infobord.png General information
  • Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination. [6]
Eenrichtingbord.png Start quetiapine
  • Start quetiapine according to the general dosing advice.
Letopbord.png Cave
  • During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. [7]


  1. ↑ Farmacotherapeutisch Kompas - lithium (dutch)
  2. ↑ 2.02.12.2 KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
  3. ↑ NVZA; Toxicology.org; Monografie 73 (dutch)
  4. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  5. ↑ Drugs.com quetiapine-fumarate
  6. ↑ Vieta E at al, Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008 Aug;109(3):251-63. Epub 2008 Jun 24
  7. ↑ Interactions between quetiapine and lithium on drugs.com
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