Combining-Lamotrigine-Risperidone

Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to lamotrigine.

Infobord.png General information
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start risperidone
  • Start risperidone according to the general dosing advice.
Letopbord.png Cave
  • A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. [7]
  • Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. [3]


  1. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  2. ↑ Farmacotherapeutisch Kompas - lamotrigine (dutch)
  3. ↑ 3.03.1 Drugs.com lamotrigine Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
  4. ↑ 4.04.1 KNMP; Informatorium Medicamentorum 2015; Monografie "risperidon" (Dutch)
  5. ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  6. ↑ 6.06.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  7. ↑ Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.