Combining-Gabapentin-Olanzapine

Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to gabapentin.

Infobord.png General information
  • Gabapentin is eliminated unchanged by the kidney for 100%.
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  • This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. [5]
Eenrichtingbord.png Start olanzapine
  • Start olanzapine according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. [6]


  1. ↑ Farmacotherapeutisch Kompas - gabapentine (dutch)
  2. ↑ 2.02.12.22.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
  3. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  4. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  5. ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  6. ↑ Interactions between olanzapine and gabapentin on drugs.com
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