Combining-Carbamazepine-Olanzapine

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Eenrichtingbord.png Start olanzapine
  • Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. [6][7]
  • Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. [8][9]



  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. ↑ 2.02.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  3. ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. ↑ 4.04.14.24.34.4 KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  5. ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  6. ↑ Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43
  7. ↑ Interactions between carbamazepine and olanzapine on drugs.com
  8. ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
  9. ↑ Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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