Combining-Carbamazepine-Gabapentin

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Gabapentin
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX12
PubChem 3446
PubMed Gabapentin
Drugs.com gabapentin
Kompas (Dutch) Gabapentin
Wikipedia Gabapentin

Adding gabapentin to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Gabapentin is eliminated unchanged by the kidney for 100%.

 

Eenrichtingbord.png Start gabapentin
  • Start gabapentin according to the general dosing advice. Coadministration of carbamazepine with gabapentin appears to be safe, with no significant interactions. Dose adjustments and additional blood level monitoring are not necessary.[5]
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.[6]


  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ 3.03.1 Farmacotherapeutisch Kompas - carbamazepine (dutch) Cite error: Invalid <ref> tag; name "ftk" defined multiple times with different content
  4. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
  5. ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
  6. ↑ Interactions between carbamazepine and gabapentin on drugs.com
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