Combining-Carbamazepine-Aripiprazole

Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole

Adding aripiprazole to carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start aripiprazole
  • Coadministration with carbamazepine may decrease the plasma concentrations of aripiprazole via induction of CYP450 3A4 and p-glycoprotein.
  • Aripiprazole should be given at higher dosage to control psychotic symptoms. [5]
Letopbord.png Cave
  • Pharmacologic response and plasma aripiprazole levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. [5][6]


  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
  5. ↑ 5.05.1 Interactions between aripiprazole and carbamazepine on drugs.com
  6. ↑ Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8
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