Combining-Aripiprazole-Carbamazepine

Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole
Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine

Adding carbamazepine to aripiprazole.

Infobord.png General information
  • Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start carbamazepine
  • Coadministration with carbamazepine may decrease the plasma concentrations of aripiprazole via induction of CYP450 3A4 and p-glycoprotein.
  • Aripiprazole should be given at higher dosage to control psychotic symptoms. [5]
Letopbord.png Cave
  • Pharmacologic response and plasma aripiprazole levels should be monitored more closely whenever carbamazepine is added to or withdrawn from therapy. [5][6]


  1. ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. ↑ KNMP; Informatorium Medicamentorum 2015; Monografie "carbamazepine" (Dutch)
  5. ↑ 5.05.1 Interactions between aripiprazole and carbamazepine on drugs.com
  6. ↑ Strack DK et al. Antipsychotic prescribing practices following withdrawal of concomitant carbamazepine. J Psychiatr Pract. 2009 Nov;15(6):442-8
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