Switch medication from Clozapine to Penfluridol.
Stop Clozapine
-
Week 1: approx. 75% of initial dose
-
Week 2: approx. 50% of initial dose
-
Week 3: approx. 25% of initial dose
-
Week 4: approx. 12,5% of initial dose
-
Day 28: stop
Start Penfluridol
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Week 1: start with 10 mg
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Week 2: increase dose to 20 mg
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Week 3 and further: adjust dose according to clinical presentation
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
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