- Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.
- Day 1: Start vortioxetine with a dosage of 5 mg/day.
- Day 8: increase dosage of vortioxetine to a dosage of 10 mg/day.
- Bupropion slows the metabolism of vortioxetine via CYP2D6
- Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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