Switch medication from bupropion to venlafaxine.[1][2]
Stop bupropion
-
Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start venlafaxine
-
Day 1: Start venlafaxine with a dosage of 37,5 mg/day.
-
Day 8: increase dosage of venlafaxine to a dosage of 75 mg/day.
More information
- Bupropion slows the metabolism of venlafaxine by CYP2D6.
-
↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
-
↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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