Switch medication from bupropion to trazodone.[1][2]
Stop bupropion
-
Day 1: Stop bupropion.
- bupropion can be stopped abruptly for every dosage.[3]
Start trazodone
-
Day 1: Start trazodone with a dosage of 75 mg/day.
-
Day 8: If necessary, gradually increase dosage
More information
- Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
-
↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
-
↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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