Switch medication from bupropion to trazodone.
- Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
- Day 1: reduce dosage of bupropion to 150 mg/day.
- Day 8: stop administration of bupropion.
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- No wash-out period is needed.
- Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
- Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
- Pharmacokinetic interaction is not important because of low plasma levels.
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