Type Antidepressant
Group other
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Type Antidepressant
Group SSRI
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from bupropion to fluoxetine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
  • Day 1: Stop administration of bupropion
Eenrichtingbord.png Start fluoxetine
  • Day 2: Start administration of fluoxetine in a dosage of 20 mg/day.
  • After 3 weeks: If necessary, gradually increase dosage of fluoxetine to max. 60 mg/day
Infobord.png More information
  • No wash-out period is needed.
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
  • Bupropion slows the metabolism of fluoxetine by CYP2D6.
  • The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
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