Bupropion-doxepine

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from bupropion to doxepine.[2][3]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[4]
Eenrichtingbord.png Start doxepine
  • Day 1: start administration of doxepin in a low dosage of 25mg/day.
  • Day 8: increase dosage of doxepin to a dosage of 75 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of doxepin via CYP2D6.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[5]
  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  4. ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
  5. ↑ (dutch) monografie.org tricyclische-antidepressiva
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