Bupropion-clomipramine

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from bupropion to clomipramine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
  • Day 1: reduce dosage of bupropion to 150 mg/day.
  • Day 8: stop administration of bupropion.
Eenrichtingbord.png Start clomipramine
  • Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
Infobord.png More information
  • Bupropion slows the metabolism of clomipramine via CYP2D6.
  • Caution is necessary at the start of administration of clomipramine.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
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