Bupropion-clomipramine

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from bupropion to clomipramine.[1][2]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[3]
Eenrichtingbord.png Start clomipramine
  • Day 1: start administration of clomipramine in a low dosage of 37,5mg/day.
  • Day 8: increase dosage of clomipramine to a dosage of 75 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of clomipramine via CYP2D6.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[4]
  1. ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. ↑ Multidisciplinair document Afbouwen Overige Antidepressiva 2023
  4. ↑ (dutch) monografie.org tricyclische-antidepressiva
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