Aripiprazole LA-Paliperidone
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Switch medication from Aripiprazole LA to Paliperidone.
Stop Aripiprazole LA
- Day 1: Last depot injection
Start Paliperidone
- Week 1-3: approx. 25% of target dose
- Week 4-6: approx. 50% of target dose
- Week 7-9: approx. 75% of target dose
- Week 10: target dose
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
- More information you'll find in the summary of product characteristics (SPC) of aripiprazole depot injection. [2]
— Aripiprazole LA
— Paliperidone
— Paliperidone
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002755/WC500156111.pdf SPC of the European Medicines Agency on aripiprazole depot
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