Switch medication from amitriptyline to trazodone.[1][2]
Stop amitriptyline
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Day 1: Decrease with about 25% of the original dose per 3 days.
Start trazodone
-
Day 1: Start with 50% of the target dose
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Day 8: Increase dose to 100% of the target dose
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Day 9 and after: Gradually increase dose as necessary
More information
- Safe target dose trazodone = 150 mg
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↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
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↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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