Amitriptyline-fluoxetine

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from amitriptyline to fluoxetine.[1][2]

Nietinrijdenbord.png Stop amitriptyline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start fluoxetine
  • Day 6 and after: At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose.
  • After 3 weeks: If necessary, gradually increase dosage of fluoxetine.
Infobord.png More information
  • Safe target dose fluoxetine = 20 mg
  • Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolizes nortriptyline, (a metabolite of amitriptyline).
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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