Amitriptyline-bupropion

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion

Switch medication from amitriptyline to bupropion.

Nietinrijdenbord.png Stop amitriptyline
  • Before day 1: gradually reduce dosage of amitriptyline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of amitriptyline to 50 mg/day.
  • Day 8: reduce dosage of amitriptyline to 25 mg/day.
  • Day 15: stop administration of amitriptyline.
Eenrichtingbord.png Start bupropion
  • Day 8: start administration of bupropion in a dosage of 150 mg/day.
Infobord.png More information
  • Bupropion is a strong inhibitor of CYP2D6, which metabolizes amitriptyline.
  • The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
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