Switch medication from Amisulpride to Clozapine.
Stop Amisulpride
-
Day 1-4: approx. 75% of initial dose
-
Day 5-8: approx. 50% of initial dose
-
Day 9-12: approx. 25% of initial dose
-
Day 13: stop
Start Clozapine
-
Day 1: start with 12,5 mg at night
-
Day 2: 25 mg in divided doses
-
Day 3-15: increase daily dose every 1-2 day(s) with 25 mg
-
Day 16-28: if necessary, increase dose with 50-100 mg/week
- Low dose in the morning, high dose at night (twice daily dosage)
- Increments are dependent on the status of patient
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[1]
— Amisulpride
— Clozapine
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