- Day 1: Stop agomelatine.
- Agomelatine can be stopped abruptly for every dosage.
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- Therapeutic Drug Monitoring of amitriptyline is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.
- A wash-out period is not necessary.
- Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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