- Author
-
R.J.T. Mocking
- Title
- Fatty acids in context
- Subtitle
- Neurometabolic perspectives on depression vulnerability
- Supervisors
-
A.H. Schene
- Co-supervisors
-
J. Assies
H.G. Ruhé - Award date
- 10 November 2017
- Number of pages
- 355
- ISBN
- 978-94-91715-15-0
- ISBN (electronic)
- 978-94-91715-16-7
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
The aim of this thesis was to focus on fatty acids and their relation with other (patho)physiological aspects in Major Depressive Disorder (MDD), in order to improve disease understanding. By conducting several studies on the role of fatty acids in the pathophysiology, recurrence and treatment of MDD, we looked for new ways beyond the monoaminergic theory to (I) improve the understanding of interactions among pathophysiological aspects, (II) reduce MDD heterogeneity by definition of subgroups with more comparable diagnostic characteristics, and (III) delineate profiles associated with prognosis and treatment outcome. This to provide anchor points to personalize treatment in the future, in order to increase treatment efficacy, reduce recurrence rates, and minimize cardiovascular comorbidity. Ultimately, we aimed to open new opportunities to reduce the burden of disease by MDD and related psychiatric disorders.
- Persistent Identifier
- https://hdl.handle.net/11245.1/97c6415f-6aa2-4ea9-a90d-056976982d0e
- Downloads
-
THESIS (complete)
Front matter
PART I: General introduction
PART II: Fatty acids - alterations in MDD: Introduction
Part II - Chapter 1: Statistical methodological issues in handling of fatty acid data: Percentage or concentration, imputation and indices
Part II - Chapter 2: Bimodal distribution of fatty acids in recurrent major depressive disorder
Part II - Chapter 3: Ala54Thr fatty acid-binding protein 2 (FABP2) polymorphism in recurrent depression: associations with fatty acid concentrations and waist circumference
Part II - Overall discussion
PART III: Context - alterations in other pathophysiological aspects in MDD: Introduction
Part III - Chapter 4: Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression
Part III - Chapter 5: DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?
Part III - Discussion of neuroendocrinological stress
Part III - Introduction to emotional processing
Part III - Chapter 6: State-dependent differences in emotion regulation between unmedicated bipolar disorder and major depressive disorder
Part III - Discussion of emotional processing, overall conclusion
PART IV: Fatty acids in context - relationships between fatty acids and other pathophysio- logical aspects: Introduction
Part IV - Chapter 7: Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression
Part IV - Chapter 8: Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response
Part IV - Chapter 9: Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co- morbid depression: a randomized controlled trial
Part IV - Chapter 10: Biological profiling of prospective antidepressant response in major depressive disorder: Associations with (neuro)inflammation, fatty acid metabolism, and amygdala-reactivity
Part IV - Discussion
PART V: Clinical implications: Introduction
Part V - Chapter 11: Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder
Part V - Chapter 12: Omega-3 fatty acid supplementation for peripartum depression: a meta-analysis
Part V - Chapter 13: Maternal depression and child development after prenatal DHA supplementation
Part V - Chapter 14: Effects of omega-3 fatty acid supplementation on oxidative stress in humans: A meta-analysis of randomized placebo-controlled trials
Part V - Discussion
PART VI: Summary and general discussion
PART VII: Appendices
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.