Risperidone-Aripiprazole
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Switch medication from Risperidone to Aripiprazole.
Stop Risperidone
- Day 1-4: approx. 75% of initial dose
- Day 5-8: approx. 50% of initial dose
- Day 9-12: approx. 25% of initial dose
- Day 13: stop
Start Aripiprazole
- Day 1-3: start 50% of target dose
- Day 4-7: target dose
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[4]
— Risperidone
— Aripiprazole
— Aripiprazole
- ↑ 1.01.1 KNMP; Informatorium Medicamentorum 2015; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 3.03.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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